https://www.exosomaltherapy.co.uk/ The science desk for regenerative aesthetics. What an exosome is, what the evidence shows, and where it is thin. Graded against a published vocabulary. en-GB Sun, 09 Aug 2026 15:31:50 +0000 Northbank Media 2026 Northbank Media editorial@exosomaltherapy.co.uk (Northbank Media) https://www.exosomaltherapy.co.uk/vesicle-science/why-nanoparticle-count-is-not-a-dose https://www.exosomaltherapy.co.uk/vesicle-science/why-nanoparticle-count-is-not-a-dose Sat, 01 Aug 2026 09:00:00 +0000 Particle counts, potency and the difference between how much material is present and how much active principle is delivered. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/what-is-inside-an-extracellular-vesicle https://www.exosomaltherapy.co.uk/vesicle-science/what-is-inside-an-extracellular-vesicle Sat, 01 Aug 2026 09:00:00 +0000 Proteins, lipids and nucleic acids in vesicle cargo, why cargo lists are easy to produce, and why a list is not a mechanism. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/what-an-exosome-actually-is https://www.exosomaltherapy.co.uk/vesicle-science/what-an-exosome-actually-is Sat, 01 Aug 2026 09:00:00 +0000 The biological definition of an exosome, the reason specialists prefer the term extracellular vesicle, and why the commercial usage is broader. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/paracrine-signalling-explained https://www.exosomaltherapy.co.uk/vesicle-science/paracrine-signalling-explained Sat, 01 Aug 2026 09:00:00 +0000 What paracrine signalling means, how the paracrine hypothesis shifted regenerative medicine away from cell replacement, and what it does and does not license. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/how-vesicles-are-taken-up-by-cells https://www.exosomaltherapy.co.uk/vesicle-science/how-vesicles-are-taken-up-by-cells Sat, 01 Aug 2026 09:00:00 +0000 Endocytosis, membrane fusion and the fate of vesicle contents inside a recipient cell, and why a fluorescent signal is not proof of functional delivery. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/how-extracellular-vesicles-are-made https://www.exosomaltherapy.co.uk/vesicle-science/how-extracellular-vesicles-are-made Sat, 01 Aug 2026 09:00:00 +0000 Biogenesis of exosomes and plasma membrane vesicles, why the two routes are hard to separate, and what that means for any product claim. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/conditioned-media-and-the-secretome https://www.exosomaltherapy.co.uk/vesicle-science/conditioned-media-and-the-secretome Sat, 01 Aug 2026 09:00:00 +0000 What conditioned culture medium is, what the secretome includes, and why many products described as exosome products are better described as secretome concentrates. Exosomal Therapy https://www.exosomaltherapy.co.uk/vesicle-science/can-a-vesicle-cross-the-skin-barrier https://www.exosomaltherapy.co.uk/vesicle-science/can-a-vesicle-cross-the-skin-barrier Sat, 01 Aug 2026 09:00:00 +0000 The stratum corneum as a size barrier, what is known about nanoparticle penetration, and why route of application is the central unanswered question. Exosomal Therapy https://www.exosomaltherapy.co.uk/the-rise-of-regenerative-aesthetics-in-london-inside-mesglo-london-and-the-future-of-skin-science https://www.exosomaltherapy.co.uk/the-rise-of-regenerative-aesthetics-in-london-inside-mesglo-london-and-the-future-of-skin-science Sat, 01 Aug 2026 09:00:00 +0000 A London scene report on where regenerative aesthetics is practised, how the category took hold in the capital, and what the science does and does not support. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/why-the-cell-source-matters https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/why-the-cell-source-matters Sat, 01 Aug 2026 09:00:00 +0000 Cell type, donor, tissue of origin and passage number change what a preparation contains. None of these are visible on a box. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/what-a-certificate-of-analysis-does-and-does-not-tell-you https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/what-a-certificate-of-analysis-does-and-does-not-tell-you Sat, 01 Aug 2026 09:00:00 +0000 How to read a certificate of analysis, what a certificate can establish, and the four things it is routinely used to imply but cannot support. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/sterility-endotoxin-and-cold-chain https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/sterility-endotoxin-and-cold-chain Sat, 01 Aug 2026 09:00:00 +0000 Why a product applied to breached skin raises sterility questions, what endotoxin is, and how storage and transport can change a preparation before use. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/isolation-methods-compared https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/isolation-methods-compared Sat, 01 Aug 2026 09:00:00 +0000 Ultracentrifugation, size exclusion chromatography, tangential flow filtration and precipitation, and what each keeps and discards. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/characterisation-what-a-real-spec-sheet-shows https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/characterisation-what-a-real-spec-sheet-shows Sat, 01 Aug 2026 09:00:00 +0000 The measurements that constitute proper characterisation of a vesicle preparation, and how to tell a specification from a description. Exosomal Therapy https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/batch-to-batch-variability https://www.exosomaltherapy.co.uk/sourcing-and-manufacture/batch-to-batch-variability Sat, 01 Aug 2026 09:00:00 +0000 Why biological products vary between batches, what comparability means, and why a study of one batch is not a study of a product. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/why-jurisdictions-diverge https://www.exosomaltherapy.co.uk/regulation/why-jurisdictions-diverge Sat, 01 Aug 2026 09:00:00 +0000 How the same product can be lawful in one country and not in another without either regulator being wrong, and why availability abroad proves nothing. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/topical-after-microneedling-is-a-different-question https://www.exosomaltherapy.co.uk/regulation/topical-after-microneedling-is-a-different-question Sat, 01 Aug 2026 09:00:00 +0000 Why applying a preparation to deliberately breached skin sits awkwardly between topical use and administration, and what is settled versus unsettled. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/the-uk-position-on-exosome-products https://www.exosomaltherapy.co.uk/regulation/the-uk-position-on-exosome-products Sat, 01 Aug 2026 09:00:00 +0000 What can and cannot be said about the regulatory status of exosome products in the UK, which framework applies, and where the position is genuinely unsettled. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/human-tissue-considerations https://www.exosomaltherapy.co.uk/regulation/human-tissue-considerations Sat, 01 Aug 2026 09:00:00 +0000 What engages human tissue law when a product derives from human cells, and the cosmetics restriction on materials of human origin. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/borderline-products-and-the-mhra https://www.exosomaltherapy.co.uk/regulation/borderline-products-and-the-mhra Sat, 01 Aug 2026 09:00:00 +0000 How the medicines definition works through presentation and function, why marketing claims can change a product's classification, and how to apply the test yourself. Exosomal Therapy https://www.exosomaltherapy.co.uk/regulation/advertising-claims-and-the-asa https://www.exosomaltherapy.co.uk/regulation/advertising-claims-and-the-asa Sat, 01 Aug 2026 09:00:00 +0000 How advertising rules apply to aesthetic claims, the substantiation requirement, and why a claim that cannot be evidenced should not be made. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/what-regenerative-actually-means https://www.exosomaltherapy.co.uk/regenerative-family/what-regenerative-actually-means Sat, 01 Aug 2026 09:00:00 +0000 Regeneration, repair and remodelling are different biological outcomes. Most aesthetic treatments described as regenerative produce the second or third. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/stem-cells-versus-cell-free-products https://www.exosomaltherapy.co.uk/regenerative-family/stem-cells-versus-cell-free-products Sat, 01 Aug 2026 09:00:00 +0000 What a stem cell product is, what cell-free means, and why the difference matters both biologically and for how a product is regulated. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/skin-boosters-and-what-they-are-not https://www.exosomaltherapy.co.uk/regenerative-family/skin-boosters-and-what-they-are-not Sat, 01 Aug 2026 09:00:00 +0000 What a skin booster does physically, why hydration is a real but distinct effect, and where the category gets conflated with signalling treatments. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/prp-and-prf-what-differs https://www.exosomaltherapy.co.uk/regenerative-family/prp-and-prf-what-differs Sat, 01 Aug 2026 09:00:00 +0000 Platelet rich plasma and platelet rich fibrin, how preparation changes composition, and why heterogeneous protocols make the literature hard to pool. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/polynucleotides-what-the-molecule-is https://www.exosomaltherapy.co.uk/regenerative-family/polynucleotides-what-the-molecule-is Sat, 01 Aug 2026 09:00:00 +0000 What polynucleotide injectables are made of, the proposed mechanisms, and how the evidence for them compares with the confidence of the marketing. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/microneedling-as-a-delivery-route https://www.exosomaltherapy.co.uk/regenerative-family/microneedling-as-a-delivery-route Sat, 01 Aug 2026 09:00:00 +0000 Why microneedling is paired with topical preparations, what it does on its own, and why that makes attribution of results unusually difficult. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/growth-factors-in-topical-and-injectable-products https://www.exosomaltherapy.co.uk/regenerative-family/growth-factors-in-topical-and-injectable-products Sat, 01 Aug 2026 09:00:00 +0000 What growth factors are, why size and stability limit topical delivery, and what a growth factor claim on a label does and does not establish. Exosomal Therapy https://www.exosomaltherapy.co.uk/regenerative-family/biostimulatory-injectables-explained https://www.exosomaltherapy.co.uk/regenerative-family/biostimulatory-injectables-explained Sat, 01 Aug 2026 09:00:00 +0000 Poly-L-lactic acid and calcium hydroxylapatite work by provoking a controlled tissue response to a foreign material. What that means for results and for risk. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/translation-failure-is-normal https://www.exosomaltherapy.co.uk/reading-the-evidence/translation-failure-is-normal Sat, 01 Aug 2026 09:00:00 +0000 Why most promising laboratory findings do not become treatments, what that says about a field, and how to read early results without cynicism. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/sample-size-and-what-it-buys-you https://www.exosomaltherapy.co.uk/reading-the-evidence/sample-size-and-what-it-buys-you Sat, 01 Aug 2026 09:00:00 +0000 Why small studies produce unreliable estimates, what statistical power means in practice, and why a small positive study should not raise your confidence much. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/preprints-and-what-peer-review-does https://www.exosomaltherapy.co.uk/reading-the-evidence/preprints-and-what-peer-review-does Sat, 01 Aug 2026 09:00:00 +0000 What peer review checks and what it does not, why a preprint is not worthless, and how predatory journals complicate the picture. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/in-vitro-in-vivo-in-human https://www.exosomaltherapy.co.uk/reading-the-evidence/in-vitro-in-vivo-in-human Sat, 01 Aug 2026 09:00:00 +0000 What each level of evidence can establish, why the gaps between them are where most claims fail, and how to place a study on the ladder. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/endpoints-that-mean-something https://www.exosomaltherapy.co.uk/reading-the-evidence/endpoints-that-mean-something Sat, 01 Aug 2026 09:00:00 +0000 Surrogate versus clinical endpoints, why appearance scales are harder than they look, and how endpoint choice decides what a study can claim. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/controls-blinding-and-the-split-face-design https://www.exosomaltherapy.co.uk/reading-the-evidence/controls-blinding-and-the-split-face-design Sat, 01 Aug 2026 09:00:00 +0000 Why the control arm decides what a study can conclude, what blinding protects against, and the specific strengths and limits of split face designs in aesthetics. Exosomal Therapy https://www.exosomaltherapy.co.uk/reading-the-evidence/conflicts-of-interest-and-how-to-find-them https://www.exosomaltherapy.co.uk/reading-the-evidence/conflicts-of-interest-and-how-to-find-them Sat, 01 Aug 2026 09:00:00 +0000 Where disclosures live in a paper, what funding and authorship arrangements do to results, and why disclosure is a starting point rather than a resolution. Exosomal Therapy