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Exosomal Therapy science desk Regenerative aesthetics, read at the level of the evidence Reviewed 1 August 2026
Exosomal TherapyThe science desk for regenerative aesthetics
The science briefing

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What arrives

One email a fortnight, with three fixed sections and nothing else. It is written for people who read methods sections, so it states the design of a study rather than its conclusion.

  • Published this fortnight. What appeared, at what level of evidence, with the design stated rather than the conclusion. If a study is a cell culture study, we say so in the first clause.
  • Grades that moved. Which claims changed position on our scale, in which direction, and against which line in the original panel.
  • One thing worth reading properly. A single paper or guidance document, with what to look for in its methods.

It is not a product newsletter. We do not announce launches, we do not carry supplier news, and we do not reproduce manufacturer claims even to disagree with them unless there is something specific to examine. Each issue carries one labelled sponsor line at the foot, which buys that line and nothing else: not a mention in the editorial, not influence over what is covered, not sight of the issue before it is sent, and no effect on an evidence grade.

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Removal on request

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Start here

Four places to begin while you wait

The briefing assumes the vocabulary on these pages, so they are the quickest way into the way this desk reads evidence.

Instrument

The grading vocabulary

The fixed scale every claim on this site is graded against, and what each position does and does not assert. The briefing reports movements on this scale.

Read Section

Reading the evidence

In vitro, in vivo and in human; what a sample size buys you; controls, blinding and the split face design; and why translation failure is normal rather than scandalous.

Section Section

Vesicle science

What an exosome actually is, how extracellular vesicles are made and taken up, why a nanoparticle count is not a dose, and whether a vesicle crosses the skin barrier.

Section Section

Regulation

The UK position on exosome products, why topical use after microneedling is a different question, borderline products and the MHRA, and human tissue considerations.

Section