Sourcing and manufacture
Cell source, culture, isolation, characterisation and batch control. The part that decides what is in the vial.
Why the cell source matters more than the brand
Cell type, donor, tissue of origin and passage number change what a preparation contains. None of these are visible on a box.
Isolation methods compared
Ultracentrifugation, size exclusion chromatography, tangential flow filtration and precipitation, and what each keeps and discards.
What a real specification sheet shows
The measurements that constitute proper characterisation of a vesicle preparation, and how to tell a specification from a description.
Sterility, endotoxin and cold chain
Why a product applied to breached skin raises sterility questions, what endotoxin is, and how storage and transport can change a preparation before use.
Batch to batch variability
Why biological products vary between batches, what comparability means, and why a study of one batch is not a study of a product.
What a certificate of analysis does not tell you
How to read a certificate of analysis, what a certificate can establish, and the four things it is routinely used to imply but cannot support.
The science briefing
One email a fortnight. What was published in extracellular vesicle and regenerative aesthetics research, what it actually showed, and which claims moved on our grading scale. Written for people who read the methods section.
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