A small trial conducted on 11 patients with androgenetic alopecia who received this combination treatment revealed a reversal of hair loss by 51.6%. Human BMSC-EVs could stimulate the proliferation of human DPCs and ORSCs in vitro, increase the level of the beta-catenin target transcription factors LEF1, EP2 and Axin2 in DPCs, promote the migration of ORSCs, improve the level of keratin differentiation markers K6, K16, K17 and K75 in ORSCs and increase HS growth in cultured human HF, 53 mouse BMSC-EVs could increase the migration and proliferation of human DPCs in vitro, increase expression and secretion of IGF-1 and VEGF in PCD, improve the transformation of telogen to anagen and amplify the level of versican, Wnt5a and Wnt3a in mice, 54 In a retrospective study conducted in the United States, 22 women and 9 men suffering from alopecia were enrolled, treated with human BMSC-EV injections and followed up for a minimum of 6 months. More than 50% of female patients and about 80% of male patients showed improvements in hair growth. 55 electric vehicles made of mesenchymal stem cells from adipose tissue and dental pulp show obvious transpistomic features that human ADSCs and ADSC-EVs strongly express genes related to angiogenesis, dermal matrices and hair growth, 56 extracts of Polygonum multiflorum Thunb, which are biopulsed reagents, could improve the production of chicken embryos Electric vehicles of mesenchymal stem cells and, therefore, improve the proliferation of human PCDs in vitro, increase the expression of genes related to follicular activity IGF-1 and RAC1, the cell proliferative genes PNCA and CCND1, and decrease the expression of the TP53 and CASP2 apoptosis genes in DPCs, 57 A case report shows that electric mesenchymal stem cell vehicles from the human placenta could have an effect on permanent alopecia induced by chemotherapy, 58. While both exosomes and PRP use growth factors to stimulate hair growth, they target different components of the body.
Exosomes target existing stem cells in the scalp, while PRP stimulates tissue repair and regeneration. The injection of exosomes derived from mesenchymal stromal cells derived from the foreskin increased hair density, with sustained patient satisfaction throughout the study. The application of the exosome did not cause side effects. The applied exosome solution would then provide nutrients and key growth factors directly to the hair follicles, which has the potential to stimulate hair growth. In addition, exosomes can improve blood flow to the area being targeted by the therapy, further improving the absorption of necessary nutrients.
The researchers also note that there is a lack of data to demonstrate the long-term efficacy and safety of exosome therapy for alopecia. The measurement of the concentration of exosomes in stem cells and the determination of the size and density distribution of exosomes were performed with the Nanosight NS300 (Malvern Panalytical, England) equipped with a 488 nm laser. Studies conducted with animal models and at the cellular level have clearly demonstrated that exosomes from several cell types, including dermal papilla cells and mesenchymal stem cells, have a remarkable ability to promote hair growth, suggesting that exosomes may provide a new option for treating alopecia. Before the procedure, you will have an initial consultation to determine if you are a good candidate for exosome therapy.
Research on hair loss therapy with exosomes is still in its early stages and so far few trials have been conducted. The exosomes used in the treatment of hair loss are isolated and purified using a patented process from donated human amniotic mesenchymal stem cells. While exosome therapy is currently not legally available in the UK, research continues to suggest that it has the potential to treat hair loss one day. Ask your trichologist where the exosomes used in the hair treatments they offer come from and how this type of exosome helps with hair loss.
hair. However, this new exosomal therapy is expected to eventually become a novel and hopeful option for treating alopecia. Here, we'll go over exactly what exosome therapy is, its potential benefits for hair loss, and its safety and side effects. In addition, the transfer of membrane proteins from exosomes to recipient cells through membrane fusion facilitates the integration of exosomal content into the cellular machinery of target cells, improving the function and growth of hair follicles.
More research is needed, but because of its anti-inflammatory properties, exosome therapy can help alleviate scalp conditions such as psoriasis, tinea capital (ringworm of the scalp), folliculitis, and seborrheic dermatitis, all characterized by inflammation of the scalp. In addition to DPC-exos, mesenchymal stem cell exosomes are another focus, specifically adipose stem cell exosomes (ADSC-exos). Some studies have suggested that exosome therapy may activate hair follicle stem cells, which could also explain the reported benefits of treatment.
